With the ultimate goal of increasing human capital and tackling existing inequalities, Grand Challenges Canada has launched a new funding opportunity open to applicants in low- and middle-income countries and Canada. This challenge seeks bold ideas for products, services and implementation models that protect and nurture early brain development in a sustainable manner. Funding is open to innovative solutions that address the risk factors facing children living in adversity by promoting health and nutrition, providing enrichment and nurturing, and/or protecting against maltreatment.